Chemoenzymatic conversion of glycerol to lactic acid and glycolic acid

Abstract Catalytic valorization of raw glycerol derived from biodiesel into high-value chemicals has attracted great attention. Here, we report chemoenzymatic cascade reactions that convert to lactic acid and glycolic acid. In the enzymatic step, a coenzyme recycling system was developed 1,3-dihydroxyacetone (DHA) with yield 92.3% in potassium phosphate buffer (300 mM, pH 7.1) containing 100 mM glycerol, 2 NAD + , 242 U/mL dehydrogenase-GldA NADH oxidase-SpNox K184R at 30 °C. Subsequently, NaOH or NaClO catalyzes formation DHA. The high (72.3%) (78.2%) verify benefit approaches. Graphical